Glg1^tm1Brle
Targeted Allele Detail

Summary

• Symbol: Glg1^tm1Brle
• Name: golgi apparatus protein 1; targeted mutation 1, Brendan Lee
• MGI ID: MGI:4829764
• Gene: Glg1 Location: Chr8:111881053-111985848 bp, - strand Genetic Position: Chr8, 57.98 cM
• Alliance: Glg1^tm1Brle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163721
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 13 through 16 were replaced with a puro cassette and 3' Hprt minigene. The absence of protein expression was confirmed by western blot on brain extracts. (J:163721)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Glg1 Mutation: 65 strains or lines available

References

• Original: J:163721 Yang T, et al., E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest. 2010 Jul 1;120(7):2474-85
• All: 3 reference(s)