Cdkn2b^tm1Wff
Targeted Allele Detail

Summary

• Symbol: Cdkn2b^tm1Wff
• Name: cyclin dependent kinase inhibitor 2B; targeted mutation 1, Linda Wolff
• MGI ID: MGI:4829849
• Gene: Cdkn2b Location: Chr4:89224536-89229276 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2b^tm1Wff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163498
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed and a neo cassette with a an additional 3' loxP site was inserted within intron 2 by homologous recombination. (J:163498)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2b Mutation: 7 strains or lines available

References

• Original: J:163498 Bies J, et al., Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia. Blood. 2010 Aug 12;116(6):979-87
• All: 3 reference(s)