Del(6Slco1b2-Slco1a5)1Nki
Targeted Allele Detail

Summary

• Symbol: Del(6Slco1b2-Slco1a5)1Nki
• Name: deletion, Chr 6, the Netherlands Cancer Institute 1; deletion, Chr 6, The Netherlands Cancer Institute
• MGI ID: MGI:4830091
• Synonyms: Del1Nki, Del(6)2Ahs, Del(6Gm5724-Slco1a6)2Ahs, Del(6Slco1b2-Slco1a5)2Ahs, Slco1a/1b^-
• Gene: Del(6Slco1b2-Slco1a5)1Nki Location: Chr6:141575244-142268707 bp Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163765
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intergenic deletion, Intragenic deletion Del(6Slco1b2-Slco1a5)1Nki involves 13 genes/genome features (Gm23069, Gm23775, Gm22036 ...) View all Mutation details: Exons 3 and 4 of Slco1a5 were replaced with floxed neo cassette while exon 4 in Slco1b2 was replaced with a Pgk-thymidine kinase and floxed Pgk-hygro cassette. Cre mediated recombination remove the intervening sequence (including Gm5724, Slco1a4, Slco1a1, Gm6614, and Slco1a6). The absence of transcript expression was confirmed by RT-PCR on liver, kidney, and small intestine extracts. (J:163765)

Generation of the Del(6Slco1b2-Slco1a5)1Nki allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(6Slco1b2-Slco1a5)1Nki Mutation: 0 strains or lines available

References

• Original: J:163765 van de Steeg E, et al., Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J Clin Invest. 2010 Aug 2;120(8):2942-52
• All: 9 reference(s)