Ace^tm8Keb
Targeted Allele Detail

Summary

• Symbol: Ace^tm8Keb
• Name: angiotensin I converting enzyme; targeted mutation 8, Kenneth E Bernstein
• MGI ID: MGI:4830150
• Synonyms: ACE12
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm8Keb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163902
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 20 was replaced with one in which nucleotide substitutions result in the amino acid substitutions of lysines for histidines at positions 993 and 997 (H993K and H997K). A floxed neo cassette was inserted upstream of the modified exon. The absence of protein expression was confirmed by western blot analysis. (J:163902)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 57 strains or lines available

References

• Original: J:163902 Fuchs S, et al., Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo. Hypertension. 2008 Feb;51(2):267-74
• All: 1 reference(s)