Ace^tm8.1Keb
Targeted Allele Detail

Summary

• Symbol: Ace^tm8.1Keb
• Name: angiotensin I converting enzyme; targeted mutation 8.1, Kenneth E Bernstein
• MGI ID: MGI:4830151
• Synonyms: ACE13
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm8.1Keb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163902
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Cre mediated recombination removed the neo cassette leaving the modified exon 20 intact (H993L and H997L). The predicted protein is expected to produce a C-terminally inactive form. (J:163902)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 57 strains or lines available

Notes

J:163902 and J:163454 selected for the single renin gene locus found in C57BL/6 mice instead of the duplicated locus found in 129 mice.

References

• Original: J:163902 Fuchs S, et al., Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo. Hypertension. 2008 Feb;51(2):267-74
• All: 4 reference(s)