Chrm5^tm1Jabe
Targeted Allele Detail

Summary

• Symbol: Chrm5^tm1Jabe
• Name: cholinergic receptor, muscarinic 5; targeted mutation 1, Jacob Bendor
• MGI ID: MGI:4830172
• Synonyms: Chrm5^deltaABD, Chrm5^M5delta
• Gene: Chrm5 Location: Chr2:112309516-112311114 bp, - strand Genetic Position: Chr2, 57.02 cM
• Alliance: Chrm5^tm1Jabe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163596
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted after the single exon, which had been mutated to delete amino acids 369-386. The selection cassette was removed by cre-mediated recombination (J:163596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm5 Mutation: 40 strains or lines available

References

• Original: J:163596 Bendor J, et al., AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. EMBO J. 2010 Aug 18;29(16):2813-26
• All: 1 reference(s)