Kcnq1ot1^tm1.1Ckan
Targeted Allele Detail

Summary

• Symbol: Kcnq1ot1^tm1.1Ckan
• Name: KCNQ1 overlapping transcript 1; targeted mutation 1.1, Chandrasekhar Kanduri
• MGI ID: MGI:4830272
• Synonyms: Kcnq1ot1^delta890
• Gene: Kcnq1ot1 Location: Chr7:142766848-142850284 bp, - strand Genetic Position: Chr7, 88.15 cM
• Alliance: Kcnq1ot1^tm1.1Ckan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163857
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 890 bp silencing domain was replaced with a self-excising neo cassette. Cre mediated recombination removed the neo cassette. (J:163857)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnq1ot1 Mutation: 0 strains or lines available

References

• Original: J:163857 Mohammad F, et al., Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development. 2010 Aug 1;137(15):2493-9
• All: 1 reference(s)