Smad4^tm1.1Rdp
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1.1Rdp
• Name: SMAD family member 4; targeted mutation 1.1, Ronald DePinho
• MGI ID: MGI:4830314
• Synonyms: Smad4^-
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1.1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163858
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• LoxP sites were inserted to flank exons 8 and 9. Cre mediated recombination removed exons 8 and 9. (J:116139)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:163858 Morsut L, et al., Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development. 2010 Aug 1;137(15):2571-8
• All: 3 reference(s)