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Mcpt8tm1.1(HBEGF)Hkar
Targeted Allele Detail
Summary
Symbol: Mcpt8tm1.1(HBEGF)Hkar
Name: mast cell protease 8; targeted mutation 1.1, Hajime Karasuyama
MGI ID: MGI:4830320
Synonyms: Mcpt8DTR, Mcpt8tm1.1(DTR)Hkar
Gene: Mcpt8  Location: Chr14:56319623-56322730 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance: Mcpt8tm1.1(HBEGF)Hkar page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163761
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Mcpt8tm1.1(HBEGF)Hkar expresses 1 gene
 
Mutation detailsA vector containing an IRES-human diphtheria toxin receptor (DTR) cDNA-EGFP and a floxed neo cassette was inserted downstream of exon 5. Cre mediated recombination removed the neo cassette. GFP expression is restricted to basophils. (J:163761)
Generation of the Mcpt8tm1.1(HBEGF)Hkar allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcpt8 Mutation:  26 strains or lines available
References
Original:  J:163761 Wada T, et al., Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest. 2010 Aug 2;120(8):2867-75
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory