Dscam^2J
Spontaneous Allele Detail

Summary

• Symbol: Dscam^2J
• Name: DS cell adhesion molecule; 2 Jackson
• MGI ID: MGI:4830358
• Synonyms: scct
• Gene: Dscam Location: Chr16:96392040-96971952 bp, - strand Genetic Position: Chr16, 57.02 cM, cytoband C
• Alliance: Dscam^2J page

Retinal abnormalities in Dscam^3J/Dscam^3J and Dscam^2J/Dscam^2J mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3H/HeDiSnJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: This spontaneous mutation has a 4 base pair duplication in exon 19 resulting in a frameshift with 84 novel amino acids and a premature stop codon that truncates the protein at approximately halfway through the extracellular domain. (J:163979)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dscam Mutation: 106 strains or lines available

References

• Original: J:163979 Fuerst PG, et al., A novel null allele of mouse DSCAM survives to adulthood on an inbred C3H background with reduced phenotypic variability. Genesis. 2010 Oct 1;48(10):578-84
• All: 15 reference(s)