P3h1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: P3h1^tm1Dgen
• Name: prolyl 3-hydroxylase 1; targeted mutation 1, Deltagen
• MGI ID: MGI:4830452
• Gene: P3h1 Location: Chr4:119090112-119106172 bp, + strand Genetic Position: Chr4, 55.34 cM, cytoband D1
• Alliance: P3h1^tm1Dgen page

Reduced body size and skeletal abnormalities in P3h1^tm1Dgen/P3h1^tm1Dgen mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163884
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a lacZ-neo cassette. The absences of transcript expression was confirmed by RT-PCR. (J:163884)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P3h1 Mutation: 28 strains or lines available

References

• Original: J:163884 Vranka JA, et al., Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones. J Biol Chem. 2010 May 28;285(22):17253-62
• All: 5 reference(s)