Tg(HP-MMP1a)34-1Cha
Transgene Detail

Summary

• Symbol: Tg(HP-MMP1a)34-1Cha
• Name: transgene insertion 34-1, Kiran Chada
• MGI ID: MGI:4830474
• Transgene: Tg(HP-MMP1a)34-1Cha Location: unknown
• Alliance: Tg(HP-MMP1a)34-1Cha page

Transgene origin

• Strain of Origin: (CBA/J x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HP-MMP1a)34-1Cha expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MMP1 (4312)

  Mmp1a	(MGI:1933846)
  Mmp1b	(MGI:1933847)

• Mutation details: The human promoter drives expression of the human cDNA in the lungs. Six lines were generated (34-1, 34-2, 52, 64, 50, and 32). Lines 32-1 and 52 exhibit the highest expression levels. (J:164058)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:164058 D'Armiento J, et al., Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell. 1992 Dec 11;71(6):955-61
• All: 2 reference(s)