Speg^tm1Mkap
Targeted Allele Detail

Summary

• Symbol: Speg^tm1Mkap
• Name: SPEG complex locus; targeted mutation 1, Mark A Perrella
• MGI ID: MGI:4830540
• Gene: Speg Location: Chr1:75351941-75408964 bp, + strand Genetic Position: Chr1, 38.88 cM
• Alliance: Speg^tm1Mkap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163968
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 through 10 were replaced with a lacZ and neo cassette. The absence of protein expression of both alpha and beta isoforms was confirmed by western blot analysis on heart extracts. Beta-galactosidase staining confirmed expression of the reporter gene in the heart. (J:163968)

Expression

In Mice Carrying this Mutation:	56 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Speg Mutation: 134 strains or lines available

References

• Original: J:163968 Liu X, et al., Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation. 2009 Jan 20;119(2):261-8
• All: 3 reference(s)