Anpep^tm1.1Lsha
Targeted Allele Detail

Summary

• Symbol: Anpep^tm1.1Lsha
• Name: alanyl aminopeptidase, membrane; targeted mutation 1.1, Linda H Shapiro
• MGI ID: MGI:4830680
• Synonyms: CD13^KO, Lap1^tm1.1Lsha
• Gene: Anpep Location: Chr7:79471551-79497958 bp, - strand Genetic Position: Chr7, 45.19 cM
• Alliance: Anpep^tm1.1Lsha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163945
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 13. Cre mediated recombination removed exon 4 through exon 13 as well as the neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney, spleen, liver, and intestine extracts. (J:163945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anpep Mutation: 84 strains or lines available

References

• Original: J:163945 Winnicka B, et al., CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse. J Leukoc Biol. 2010 Aug;88(2):347-59
• All: 8 reference(s)