Rr103^tm3.1Sia
Targeted Allele Detail

Summary

• Symbol: Rr103^tm3.1Sia
• Name: regulatory region 103; targeted mutation 3.1, Shinichi Aizawa
• MGI ID: MGI:4830690
• Synonyms: Emx2^deltaFB, Emx2^tm3.1Sia
• Gene: Rr103 Location: unknown Genetic Position: Chr19, Syntenic
• Alliance: Rr103^tm3.1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163926
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The theta domain forebrain enhancer in an AflII-KpnI restriction fragment was replaced by a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette. Semi-quantitative RT-PCR and RNA in situ hydridization confirmed the lack of transcript expression in the caudal forebrain primordium at E8.5 but only a reduction in expression at E9.5 and E10.5. (J:163926)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr103 Mutation: 0 strains or lines available

References

• Original: J:163926 Suda Y, et al., The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone. Development. 2010 Sep 1;137(17):2939-49
• All: 1 reference(s)