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Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank J Slack
MGI ID: MGI:4830734
Synonyms: Gt(ROSA)26Sortm1(tetO-Mir21)Fjsl, Gt(ROSA)26Sortm1(tetO-Mirn21)Fjsl, mir-21LSL-Tetoff
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163919
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6J x SJL/J)F2
Mutation
description
Allele Type:    Targeted (Conditional ready, Inducible, Inserted expressed sequence, Transactivator)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl expresses 1 gene
 
Mutation detailsA construct was inserted into the locus that contained the following elements (5' to 3'): the tetracycline transactivator (tTA), two poly-adenylation sequences, the tetracycline operator with minimal CMV promoter, a floxed neo cassette with 4 poly-adenylation sequences, the mouse transcript, and a poly-adenylation sequence. The locus promoter drives expression of tTA while the tet operator drives expression of the transcript only after cre mediated removal of the floxed neo-STOP cassette that can be repressed by doxycycline treatment. (J:163919)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:163919 Medina PP, et al., OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature. 2010 Sep 2;467(7311):86-90
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory