Ptpn12^tm1Vei
Targeted Allele Detail

Summary

• Symbol: Ptpn12^tm1Vei
• Name: protein tyrosine phosphatase, non-receptor type 12; targeted mutation 1, Andre Veillette
• MGI ID: MGI:4830749
• Gene: Ptpn12 Location: Chr5:21191643-21260909 bp, - strand Genetic Position: Chr5, 9.83 cM, cytoband A3-B
• Alliance: Ptpn12^tm1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163910
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT flanked neo-tk selection cassette were inserted in intron 7. A second loxP site was inserted in intron 8. The selection cassette was subsequently excised from properly targeted ES cells by transient flp recombinase expression. (J:163910)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn12 Mutation: 52 strains or lines available

References

• Original: J:163910 Davidson D, et al., The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2. Immunity. 2010 Aug 27;33(2):167-80
• All: 4 reference(s)