Rela^tm2.1Gho
Targeted Allele Detail

Summary

• Symbol: Rela^tm2.1Gho
• Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 2.1, Sankar Ghosh
• MGI ID: MGI:4830882
• Synonyms: p65^PD
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm2.1Gho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163663
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Endogenous DNA sequence for residue 276 was changed from a serine to an aspartic acid (S276D) and a floxed neo cassette was inserted with intron 7 by homologous recombination. The selection cassette was removed by cre mediated recombination. (J:163663)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:163663 Dong J, et al., Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease. Genes Dev. 2010 Aug 15;24(16):1709-17
• All: 2 reference(s)