Nox4^tm1.1Jusa
Targeted Allele Detail

Summary

• Symbol: Nox4^tm1.1Jusa
• Name: NADPH oxidase 4; targeted mutation 1.1, Junichi Sadoshima
• MGI ID: MGI:4830885
• Gene: Nox4 Location: Chr7:86895304-87047918 bp, + strand Genetic Position: Chr7, 48.96 cM
• Alliance: Nox4^tm1.1Jusa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163751
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using BAC RP23-63G7 exon 9 was floxed and a FRT flanked neo cassette was inserted within intron 9, 5' to the second loxP site. The selection cassette was removed by flp mediated recombination. (J:163751)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nox4 Mutation: 68 strains or lines available

References

• Original: J:163751 Kuroda J, et al., NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15565-70
• All: 10 reference(s)