Gt(ROSA)26Sor^{tm1(NOTCH3)Sat}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(NOTCH3)Sat}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Spyros Artavanis-Tsakonas
• MGI ID: MGI:4830990
• Synonyms: WT76
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(NOTCH3)Sat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133358
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(NOTCH3)Sat} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NOTCH3 (4854)

  Notch3

  (MGI:99460)

• Mutation details: A targeting vector containing a splice acceptor site, a loxP-flanked PGK neomycin cassette, a human NOTCH3 cDNA and an IRES-nuclear GFP sequence was inserted into the GT(ROSA)26Sor locus. (J:133358)

Schematic of the Gt(ROSA)26Sor^{tm1(NOTCH3)Sat}, Gt(ROSA)26Sor^{tm2(NOTCH3*C455R)Sat} and Gt(ROSA)26Sor^{tm3(NOTCH3*R1031C)Sat} constructs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:133358 Arboleda-Velasquez JF, et al., Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4856-61
• All: 4 reference(s)