Sec61a1^m1Gek
Chemically induced Allele Detail

Summary

• Symbol: Sec61a1^m1Gek
• Name: SEC61 translocon subunit alpha 1; mutation 1, Nicholas Gekakis
• MGI ID: MGI:4830998
• Synonyms: Sec61a1^Y344H
• Gene: Sec61a1 Location: Chr6:88480589-88495782 bp, - strand Genetic Position: Chr6, 39.51 cM
• Alliance: Sec61a1^m1Gek page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transition at codon 344 that results in an amino substitution of histidine for tyrosine at position 344 (Y344H). (J:164159)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sec61a1 Mutation: 16 strains or lines available

References

• Original: J:164159 Lloyd DJ, et al., A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice. Diabetes. 2010 Feb;59(2):460-70
• All: 2 reference(s)