Tnfaip3^tm2Ama
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm2Ama
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 2, Averil Ma
• MGI ID: MGI:4831001
• Synonyms: A20^FL, Tnfaip3^fl
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm2Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163917
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct contained exon 2 flanked by loxP sites along with a loxP flanked neomycin cassette.The neomycin cassette was removed by transient transfection of Cre recombinase. (J:163917)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tnfaip3^tm2Ama

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 45 strains or lines available

References

• Original: J:163917 Tavares RM, et al., The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity. 2010 Aug 27;33(2):181-91
• All: 17 reference(s)