Cubn^tm1Rkoz
Targeted Allele Detail

Summary

• Symbol: Cubn^tm1Rkoz
• Name: cubilin; targeted mutation 1, Renata Kozyraki
• MGI ID: MGI:4831004
• Synonyms: Cubn^lox
• Gene: Cubn Location: Chr2:13281149-13496624 bp, - strand Genetic Position: Chr2, 9.86 cM
• Alliance: Cubn^tm1Rkoz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164025
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 14 was flanked with loxP sites and a hygromycin resistance cassette was inserted in intron 14. (J:164025)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cubn Mutation: 160 strains or lines available

References

• Original: J:164025 Amsellem S, et al., Cubilin is essential for albumin reabsorption in the renal proximal tubule. J Am Soc Nephrol. 2010 Nov;21(11):1859-67
• All: 7 reference(s)