Tg(Ins2-Sec61a1)#Gek
Transgene Detail

Summary

• Symbol: Tg(Ins2-Sec61a1)#Gek
• Name: transgene insertion, Nicholas Gekakis
• MGI ID: MGI:4831008
• Synonyms: Tg[Rip-Sec61]
• Transgene: Tg(Ins2-Sec61a1)#Gek Location: unknown
• Alliance: Tg(Ins2-Sec61a1)#Gek page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Sec61a1)#Gek expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sec61a1 (MGI:1858417)

• Tg(Ins2-Sec61a1)#Gek expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The rat promoter (-695 to +153 of the rat gene) drives beta-cell-specific expression of the mouse cDNA. A single founder line was established (# denotes that no line number was assigned in the publication). (J:164159)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:164159 Lloyd DJ, et al., A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice. Diabetes. 2010 Feb;59(2):460-70
• All: 1 reference(s)