Macf1^tm2.1Liem
Targeted Allele Detail

Summary

• Symbol: Macf1^tm2.1Liem
• Name: microtubule-actin crosslinking factor 1; targeted mutation 2.1, Ronald K H Liem
• MGI ID: MGI:4831018
• Synonyms: Macf1^F
• Gene: Macf1 Location: Chr4:123243426-123581331 bp, - strand Genetic Position: Chr4, 57.42 cM
• Alliance: Macf1^tm2.1Liem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164146
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6 and a floxed neo cassette was inserted downstream of exon 7. Cre mediated recombination removed the neo cassette leaving exons 6 and 7 floxed. (J:164146)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Macf1 Mutation: 854 strains or lines available

References

• Original: J:164146 Goryunov D, et al., Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain. Mol Cell Neurosci. 2010 May;44(1):1-14
• All: 3 reference(s)