Macf1^tm2.2Liem
Targeted Allele Detail

Summary

• Symbol: Macf1^tm2.2Liem
• Name: microtubule-actin crosslinking factor 1; targeted mutation 2.2, Ronald K H Liem
• MGI ID: MGI:4831019
• Synonyms: Macf1^R
• Gene: Macf1 Location: Chr4:123243426-123581331 bp, - strand Genetic Position: Chr4, 57.42 cM
• Alliance: Macf1^tm2.2Liem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164146
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed the neo cassette and exons 6 and 7. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:164146)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Macf1 Mutation: 854 strains or lines available

References

• Original: J:164146 Goryunov D, et al., Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain. Mol Cell Neurosci. 2010 May;44(1):1-14
• All: 1 reference(s)