Tg(TTR-INSR)L3Dac
Transgene Detail

Summary

• Symbol: Tg(TTR-INSR)L3Dac
• Name: transgene insertion L3, Dominico Accili
• MGI ID: MGI:4831147
• Transgene: Tg(TTR-INSR)L3Dac Location: unknown
• Alliance: Tg(TTR-INSR)L3Dac page

Transgene origin

• Strain of Origin: C57BL/6 x FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TTR-INSR)L3Dac expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  INSR (3643)

  Insr	(MGI:96575)

• Mutation details: A human insulin receptor cDNA was inserted in exon 3 of a 3kbp human TTR fragment containin the promoter and exons 1-3. The insulin receptor cDNA is thus placed under the control of the human TTR promoter. Three founder lines were established (L1, L2, L3). Highest expression was found in L1. Expression in L3 which has a copy number of 1 was 29% of expression in L1. (J:91350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:91350 Okamoto H, et al., Transgenic rescue of insulin receptor-deficient mice. J Clin Invest. 2004 Jul;114(2):214-23
• All: 1 reference(s)