Nusap1^tm1.1Gcm
Targeted Allele Detail

Summary

• Symbol: Nusap1^tm1.1Gcm
• Name: nucleolar and spindle associated protein 1; targeted mutation 1.1, Geert Carmeliet
• MGI ID: MGI:4833676
• Gene: Nusap1 Location: Chr2:119449205-119480646 bp, + strand Genetic Position: Chr2, 59.97 cM
• Alliance: Nusap1^tm1.1Gcm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164315
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin selection cassette was inserted in intron 2 and a third loxP site was inserted in intron 3. The neomycin selection cassette and exon 3 were subsequently excised by transient cre expression from properly targeted ES cells. (J:164315)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nusap1 Mutation: 37 strains or lines available

References

• Original: J:164315 Vanden Bosch A, et al., NuSAP is essential for chromatin-induced spindle formation during early embryogenesis. J Cell Sci. 2010 Oct 1;123(Pt 19):3244-55
• All: 1 reference(s)