Tg(Pomc)#Low
Transgene Detail

Summary

• Symbol: Tg(Pomc)#Low
• Name: transgene insertion, Malcolm J Low
• MGI ID: MGI:4833830
• Synonyms: pHAL*, pHalEx2*Tg
• Transgene: Tg(Pomc)#Low Location: unknown
• Alliance: Tg(Pomc)#Low page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pomc)#Low expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pomc (MGI:97742)

• Mutation details: The transgene contains a tagged 10.2 kb of the mouse gene encompassing three exons, two introns, and 2 kb of the 5' and 3' flanking sequences. The modification involves the insertion of a random 34 bp sequence in the coding sequence of exon 3, allowing for distinguishing transgene transcripts from endogenous transcripts. Six lines were generated, which all show expression in the pituitary, but lines 35 and 36 exhibit ectopic expression in the hippocampal dentate gyrus. (J:15859)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:15859 Rubinstein M, et al., Rat and mouse proopiomelanocortin gene sequences target tissue-specific expression to the pituitary gland but not to the hypothalamus of transgenic mice. Neuroendocrinology. 1993 Oct;58(4):373-80
• All: 4 reference(s)