Trip10^tm1.1Geha
Targeted Allele Detail

Summary

• Symbol: Trip10^tm1.1Geha
• Name: thyroid hormone receptor interactor 10; targeted mutation 1.1, Raif S Geha
• MGI ID: MGI:4834223
• Gene: Trip10 Location: Chr17:57556455-57570665 bp, + strand Genetic Position: Chr17, 29.74 cM
• Alliance: Trip10^tm1.1Geha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164363
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exons 4 through 11 were replaced with an FRT flanked neo cassette. Flp mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis of lung extract. (J:164363)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trip10 Mutation: 31 strains or lines available

References

• Original: J:164363 Koduru S, et al., Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16252-6
• All: 1 reference(s)