Kcnn2^bc-6J
Chemically induced Allele Detail

Summary

• Symbol: Kcnn2^bc-6J
• Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; bouncy 6 Jackson
• MGI ID: MGI:4834267
• Gene: Kcnn2 Location: Chr18:45401927-45818950 bp, + strand Genetic Position: Chr18, 24.34 cM, cytoband C
• Alliance: Kcnn2^bc-6J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: A failed complementation test with bouncy 3 Jackson proved the two allelic and exome sequencing identified a single G-to-A transversion at chromosome 18 position 45,685,419 (GRCm38) in bouncy 6 Jackson, which causes a nonsense mutation changing tryptophan to a stop codon at residue 345 in the last exon (NP_536713:p.W345*, ENSMUSP00000067884:p.W610*, NP_001299834:p.W620*). (J:215011, J:222308)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnn2 Mutation: 43 strains or lines available

References

• Original: J:215011 Harris BS, et al., The bouncy 6 Jackson allele of Kcnn2. MGI Direct Data Submission. 2014
• All: 2 reference(s)