Tardbp^tm1.1Pcw
Targeted Allele Detail

Summary

• Symbol: Tardbp^tm1.1Pcw
• Name: TAR DNA binding protein; targeted mutation 1.1, Philip C Wong
• MGI ID: MGI:4834273
• Synonyms: Tardbp^F, Tardbp^flox
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^tm1.1Pcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164406
• Parent Cell Line: V26.2 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 of the Tardbp gene was flanked by loxP sites. A neo cassette was inserted into exon 2. Mice carrying the mutant allele were crossed to Flp transgenic mice to delete the neo cassette. (J:164406)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 68 strains or lines available

References

• Original: J:164406 Chiang PM, et al., Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16320-4
• All: 21 reference(s)