Tg(MMTV-PTGS2)#Thla
Transgene Detail

Summary

• Symbol: Tg(MMTV-PTGS2)#Thla
• Name: transgene insertion, Timothy Hla
• MGI ID: MGI:4834855
• Synonyms: MMTV-COX-2
• Transgene: Tg(MMTV-PTGS2)#Thla Location: unknown
• Alliance: Tg(MMTV-PTGS2)#Thla page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-PTGS2)#Thla expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTGS2 (5743)

  Ptgs2

  (MGI:97798)

• Mutation details: The mouse mammary tumor virus promoter drives expression of human PTGS2. Three founders were created, but no line numbers were provided. Low levels of transgene expression were detected in the mammary gland in mature virgin females and expression levels were significantly induced during pregnancy and lactation. (J:68565)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:68565 Liu CH, et al., Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem. 2001 May 25;276(21):18563-9
• All: 3 reference(s)