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Cdkn2atm2.1Nesh
Targeted Allele Detail
Summary
Symbol: Cdkn2atm2.1Nesh
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Norman E Sharpless
MGI ID: MGI:4835008
Synonyms: p16INKa4a L, p16L
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance: Cdkn2atm2.1Nesh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164588
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT flanked neo cassette with a 5' loxP site was inserted upstream of exon 1 alpha. Approximately 560 bp of a non-conserved variable number tandem repeat was deleted during the insertion. An additional loxP site was inserted downstream of exon 1alpha. Flp mediated recombination removed the neo cassette leaving exon 1 alpha floxed. (J:164588)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Cdkn2atm2.1Nesh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  67 strains or lines available
References
Original:  J:164588 Monahan KB, et al., Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 2010 Oct 28;29(43):5809-17
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory