Cdkn2a^tm2.1Nesh
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm2.1Nesh
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Norman E Sharpless
• MGI ID: MGI:4835008
• Synonyms: p16INKa4a L, p16^L
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm2.1Nesh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164588
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette with a 5' loxP site was inserted upstream of exon 1 alpha. Approximately 560 bp of a non-conserved variable number tandem repeat was deleted during the insertion. An additional loxP site was inserted downstream of exon 1alpha. Flp mediated recombination removed the neo cassette leaving exon 1 alpha floxed. (J:164588)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2a^tm2.1Nesh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 67 strains or lines available

References

• Original: J:164588 Monahan KB, et al., Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 2010 Oct 28;29(43):5809-17
• All: 12 reference(s)