Tg(Atp4b-cre)3Xya
Transgene Detail

Summary

• Symbol: Tg(Atp4b-cre)3Xya
• Name: transgene insertion 3, Xiao Yang
• MGI ID: MGI:4835161
• Synonyms: Atp4b-Cre
• Transgene: Tg(Atp4b-cre)3Xya Location: unknown
• Alliance: Tg(Atp4b-cre)3Xya page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Atp4b-cre)3Xya expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Atp4b

• Mutation details: The 1.0 kb promoter of the Atp4b gene was cloned into a vector upstream of the 1.2 kb cre recombinase coding sequence and a 2.1 kb human growth hormone gene polyadenylation signal. The 4.3 kb construct was linearized and injected into pronuclei of fertilized FVB oocytes. Two founder animals (3 and 5) were obtained that had the transgene integrated into the genome. Analyses of crosses to a reporter line showed cre recombination occurred only in the stomach, detected at P13. Both lines showed the same pattern of recombination. (J:164715)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atp4b (species not specified) Summary of all recombinase alleles driven by Atp4b. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:164715 Zhao Z, et al., Atp4b promoter directs the expression of Cre recombinase in gastric parietal cells of transgenic mice. J Genet Genomics. 2010 Sep;37(9):647-52
• All: 3 reference(s)