Plp1^tm1Gow
Targeted Allele Detail

Summary

• Symbol: Plp1^tm1Gow
• Name: proteolipid protein (myelin) 1; targeted mutation 1, Alexander Gow
• MGI ID: MGI:4835262
• Synonyms: Plp neo
• Gene: Plp1 Location: ChrX:135723420-135740482 bp, + strand Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
• Alliance: Plp1^tm1Gow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62287
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The splice donor site at the 3' end of exon 3 was inactivated by site directed mutagenesis. A floxed PGKneo selection cassette was then inserted at position 49 of intron 3. Presence of the floxed neo prevents protein expression. (J:62287)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plp1 Mutation: 18 strains or lines available

References

• Original: J:62287 Stecca B, et al., The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. J Neurosci. 2000 Jun 1;20(11):4002-10
• All: 1 reference(s)