Chd7^tm1.2Dmm
Targeted Allele Detail

Summary

• Symbol: Chd7^tm1.2Dmm
• Name: chromodomain helicase DNA binding protein 7; targeted mutation 1.2, Donna M Martin
• MGI ID: MGI:4835268
• Synonyms: Chd7^-
• Gene: Chd7 Location: Chr4:8690406-8867659 bp, + strand Genetic Position: Chr4, 3.68 cM
• Alliance: Chd7^tm1.2Dmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164582
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted up stream of exon 2 and an FRT flanked neo/kan cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed the neo/kan cassette and exon 2. Immunofluorescence analysis confirmed the absence of expression at E10.5 in homozygous embryos. (J:164582)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd7 Mutation: 138 strains or lines available

References

• Original: J:164582 Hurd EA, et al., The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development. 2010 Sep;137(18):3139-50
• All: 1 reference(s)