Fgfr2^hob
Chemically induced Allele Detail

Summary

• Symbol: Fgfr2^hob
• Name: fibroblast growth factor receptor 2; hobbyhorse
• MGI ID: MGI:4835423
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^hob page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: This mutation, identified in an ENU-based forward genetic screen, results in a C to T mutation in the invariant exon 7, resulting in a polypeptide with a missense mutation at position 263 (Pro263Ser) in the third extracellular immunoglobulin-like domain. This is expected to be a hypomorphic allele. (J:216825)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:216825 Siggers P, et al., A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal. PLoS One. 2014;9(6):e100447
• All: 1 reference(s)