Cd44^tm2.1Ugu
Targeted Allele Detail

Summary

• Symbol: Cd44^tm2.1Ugu
• Name: CD44 antigen; targeted mutation 2.1, Ursula Gunthert
• MGI ID: MGI:4835490
• Synonyms: CD44^v10-/-, CD44v10-/-
• Gene: Cd44 Location: Chr2:102641486-102732010 bp, - strand Genetic Position: Chr2, 54.13 cM
• Alliance: Cd44^tm2.1Ugu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated from Cd44^tm2Ugu by Cre recombinase excision of the neomycin resistance cassette and exon 10. (J:199279)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Cd44 Mutation: 72 strains or lines available

References

• Original: J:199279 Ghazi-Visser L, et al., CD44 variant isoforms control experimental autoimmune encephalomyelitis by affecting the lifespan of the pathogenic T cells. FASEB J. 2013 Sep;27(9):3683-701
• All: 3 reference(s)