Nlrp3^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp3^m3Btlr
• Name: NLR family, pyrin domain containing 3; mutation 3, Bruce Beutler
• MGI ID: MGI:4835554
• Synonyms: ND6
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The ND6 mutation corresponds to an A to G transition at position 1982 of the transcript, in exon 9 of 10 total exons (Genbank record NM_145827). The mutation is located in the third coding exon and causes an arginine to glycine substitution at amino acid 586 of the protein. (J:164866)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 64 strains or lines available

References

• Original: J:164866 Beutler B, ND6 is an allele of Nlrp3 and causes reduced macrophage IL-1beta response to LPS and nigericin. MGI Direct Data Submission. 2010
• All: 1 reference(s)