Slc15a4^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Slc15a4^m1Btlr
• Name: solute carrier family 15, member 4; mutation 1, Bruce Beutler
• MGI ID: MGI:4835997
• Synonyms: feeble
• Gene: Slc15a4 Location: Chr5:127672728-127709961 bp, - strand Genetic Position: Chr5, 66.0 cM
• Alliance: Slc15a4^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• The feeble mutation has been identified as a T to A transversion in the intron 2 donor splice site. (J:86521, J:166600) Additional incidental mutations were detected in sequencing for the causative mutation, Slc15a4^m1Btlr, and may be present in stocks carrying this mutation.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc15a4 Mutation: 43 strains or lines available

References

• Original: J:166600 Blasius AL, et al., Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19973-8
• All: 9 reference(s)