Tg(Ins2-IGF1R)1Dh
Transgene Detail

Summary

• Symbol: Tg(Ins2-IGF1R)1Dh
• Name: transgene insertion 1, Douglas Hanahan
• MGI ID: MGI:4836169
• Synonyms: RIP7-IGF-1R
• Transgene: Tg(Ins2-IGF1R)1Dh Location: unknown
• Alliance: Tg(Ins2-IGF1R)1Dh page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-IGF1R)1Dh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1R (3480)

  Igf1r

  (MGI:96433)

• Tg(Ins2-IGF1R)1Dh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: A 4.4 kb full length cDNA clone of the human insulin-like growth factor type 1 receptor was placed unber the control of the 9.5 kb rat insulin II 5' regulatory region (RIP7). Several founder mice were identified. Line 1 is described in detail. (J:76998, J:77136)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Tg(Ins2-IGF1R)1Dh/0 Tg(RIP1-Tag)2Dh/0	involves: C3H * C57BL/6 * C57BL/6J * DBA/2J

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms
endocrine/exocrine glands	√
increased insulinoma incidence	√
increased pancreatic islet cell carcinoma incidence	√
mortality/aging	√
premature death	√
neoplasm	√
increased insulinoma incidence	√
increased pancreatic islet cell carcinoma incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77136 Lopez T, et al., Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell. 2002 May;1(4):339-53
• All: 3 reference(s)