Tg(Camk2a-AIDPak)21Stl
Transgene Detail

Summary

• Symbol: Tg(Camk2a-AIDPak)21Stl
• Name: transgene insertion 21, Susumu Tonegawa
• MGI ID: MGI:4836192
• Synonyms: dnPAK
• Transgene: Tg(Camk2a-AIDPak)21Stl Location: unknown
• Alliance: Tg(Camk2a-AIDPak)21Stl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-AIDPak)21Stl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pak3 (MGI:1339656)

• Mutation details: The dnPAK transgene was designed with the mouse autoinhibitory domain (AID) of the p21 protein (Cdc42/Rac)-activated kinase 3 (Pak3) gene tagged with myc and driven by a mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter, followed by a simian virus 40 (SV40) polyadenylation site. This domain is conserved in all three Pak genes (Pak1, Pak2, Pak3). Lines 21 and 110 were generated. (J:90763)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:90763 Hayashi ML, et al., Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice. Neuron. 2004 Jun 10;42(5):773-87
• All: 4 reference(s)