Prkaa2^tm1.1Sjm
Targeted Allele Detail

Summary

• Symbol: Prkaa2^tm1.1Sjm
• Name: protein kinase, AMP-activated, alpha 2 catalytic subunit; targeted mutation 1.1, Sean J Morrison
• MGI ID: MGI:4836201
• Synonyms: Ampka2^fl, Prkaa2^fl
• Gene: Prkaa2 Location: Chr4:104887071-104967087 bp, - strand Genetic Position: Chr4, 49.05 cM
• Alliance: Prkaa2^tm1.1Sjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165090
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo selection cassette. (J:165090)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkaa2 Mutation: 35 strains or lines available

References

• Original: J:165090 Nakada D, et al., Lkb1 regulates cell cycle and energy metabolism in hematopoietic stem cells. Nature. 2010;468(7324):653-658
• All: 42 reference(s)