Cyp51^tm1.1Bfro
Targeted Allele Detail

Summary

• Symbol: Cyp51^tm1.1Bfro
• Name: cytochrome P450, family 51; targeted mutation 1.1, Simon Horvat
• MGI ID: MGI:4836362
• Gene: Cyp51 Location: Chr5:4131145-4154746 bp, - strand Genetic Position: Chr5, 2.3 cM, cytoband A2
• Alliance: Cyp51^tm1.1Bfro page

Morphological developmental abnormalities in Cyp51^tm1.1Bfro/Cyp51^tm1.1Bfro embryos

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173366
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Intragenic deletion Mutation details: Exons 3 and 4 were excised by crossing Cyp51 mice to Tg(EIIa-cre)C5379Lmgd mice. Absence of gene expression was confirmed by quantitative RT-PCR. No immunologically detectable protein was observed on Western blots. (J:173366)

Generation of the Cyp51^tm1Bfro and Cyp51^tm1.1Bfro alleles

Expression

In Structures Affected by this Mutation:

20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp51 Mutation: 24 strains or lines available

References

• Original: J:173366 Keber R, et al., Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. J Biol Chem. 2011 Aug 19;286(33):29086-97
• All: 5 reference(s)