Nedd4^tm2Bros
Targeted Allele Detail

Summary

• Symbol: Nedd4^tm2Bros
• Name: neural precursor cell expressed, developmentally down-regulated 4; targeted mutation 2, Nils Brose
• MGI ID: MGI:4836403
• Gene: Nedd4 Location: Chr9:72569628-72657134 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Nedd4^tm2Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7 and 8 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:164745)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nedd4 Mutation: 116 strains or lines available

References

• Original: J:164745 Kawabe H, et al., Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron. 2010 Feb 11;65(3):358-72
• All: 1 reference(s)