Nedd4^tm3.1Bros
Targeted Allele Detail

Summary

• Symbol: Nedd4^tm3.1Bros
• Name: neural precursor cell expressed, developmentally down-regulated 4; targeted mutation 3.1, Nils Brose
• MGI ID: MGI:4836405
• Synonyms: Nedd4-1^flox
• Gene: Nedd4 Location: Chr9:72569628-72657134 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Nedd4^tm3.1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette with a 3' loxP site was inserted upstream of exon 9 and an additional loxP site was inserted downstream of exon 9. Flp mediated recombination removed the neo cassette leaving exon 9 floxed. (J:164745)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nedd4 Mutation: 116 strains or lines available

References

• Original: J:164745 Kawabe H, et al., Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron. 2010 Feb 11;65(3):358-72
• All: 11 reference(s)