Pla2g10^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Pla2g10^tm1Itl
• Name: phospholipase A2, group X; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:4836546
• Synonyms: GX sPLA2^-, Pla2g10^tm1Igl
• Gene: Pla2g10 Location: Chr16:13532921-13548847 bp, - strand Genetic Position: Chr16, 9.5 cM
• Alliance: Pla2g10^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164545
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced 564 bp of exon 1. The absence of protein expression was confirmed by immunohistochemistry on adrenal glands. (J:164545)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pla2g10 Mutation: 31 strains or lines available

References

• Original: J:164545 Shridas P, et al., Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands. J Biol Chem. 2010 Jun 25;285(26):20031-9
• All: 6 reference(s)