Lclat1^tm1Yugs
Targeted Allele Detail

Summary

• Symbol: Lclat1^tm1Yugs
• Name: lysocardiolipin acyltransferase 1; targeted mutation 1, Yuguang Shi
• MGI ID: MGI:4836722
• Gene: Lclat1 Location: Chr17:73414980-73550363 bp, + strand Genetic Position: Chr17, 44.79 cM
• Alliance: Lclat1^tm1Yugs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a neo cassette. (J:163077)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lclat1 Mutation: 25 strains or lines available

References

• Original: J:163077 Li J, et al., Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab. 2010 Aug 4;12(2):154-65
• All: 6 reference(s)