Tfpi^tm1.1Rdsi
Targeted Allele Detail

Summary

• Symbol: Tfpi^tm1.1Rdsi
• Name: tissue factor pathway inhibitor; targeted mutation 1.1, Robert D Simari
• MGI ID: MGI:4836740
• Gene: Tfpi Location: Chr2:84263199-84307119 bp, - strand Genetic Position: Chr2, 49.41 cM
• Alliance: Tfpi^tm1.1Rdsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164530
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A FRT flanked Neomycin cassette was inserted within intron 3 and exon 4 was floxed by homologous recombination. The selection cassette was removed by flp mediated recombination. (J:164530)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfpi Mutation: 47 strains or lines available

References

• Original: J:164530 White TA, et al., Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood. 2010 Sep 9;116(10):1787-94
• All: 3 reference(s)